Appleton is a city in Outagamie (mostly), Calumet, and Winnebago counties in the U.S. state of Wisconsin. One of the Fox Cities, it is situated on the Fox River, 30 miles (48 km) southwest of Green Bay and 100 miles (160 km) north of Milwaukee. Appleton is the county seat of Outagamie County. The population was 72,623 at the 2010 census. Of this, 60,045 were in Outagamie County, 11,088 in Calumet County, and 1,490 in Winnebago County. Appleton is the principal city of the Appleton, Wisconsin Metropolitan Statistical Area, which is included in the Appleton-Oshkosh-Neenah, Wisconsin Combined Statistical Area. The city possesses the two tallest buildings in Outagamie County, the Zuelke Building and 222 Building, at 168 and 183 feet, respectively. Appleton serves as the heart of the Fox River Valley, and is home to the Fox Cities Exhibition Center, Fox Cities Performing Arts Center, Fox River Mall, Neuroscience Group Field at Fox Cities Stadium, Appleton International Airport, and the Valley's two major hospitals: St. Elizabeth Hospital and ThedaCare Regional Medical Center–Appleton. It also hosts a large number of regional events such as its Flag Day parade, Christmas parade, Octoberfest and others.
Appleton is home to Lawrence University, a private liberal arts college, and Fox Valley Technical College. Globe University, Concordia University Wisconsin, and Rasmussen College have branch campuses in the city. The University of Wisconsin–Fox Valley, a two-year campus of the University of Wisconsin System, is located in nearby Menasha.